Pretreatment with water kefir reduces the development of acidified ethanol-induced gastric ulcers

To evaluate the gastroprotective and antioxidant effects of pretreatment with water kefir on ulcers induced HCl/ethanol. All pretreatments lasted 14 days. Male mice were separated into five groups: control (C) group received vehicle without ulcer induction; ulcerated (U) vehicle; lansoprazole (L) 30 mg/kg/day lansoprazole; (WK15 WK30) groups WK at a dose 0.15 or 0.30 ml/kg/day, respectively. Gastroprotection was measured by area, index reduction percentage. Antioxidant quantified measuring advanced oxidized protein products (AOPPs), superoxide dismutase (SOD), catalase activity in stomach. Pretreatment both doses promoted gastroprotection against HCl/ethanol-induced much like lansoprazole. In addition, decreased oxidation while increasing SOD activity. We concluded that increases enzymes, preventing gastric lesions HCl/ethanol maintaining performance tissue.